Bioprocessing for Modern Living

Targeted metabolomics for bioprocessing

Background Bioprocesses like the cell-based production of biologicals, i.e. mainly recombinant proteins and monoclonal antibodies, require optimal culture conditions to obtain a high yield of quality products. The performance of a bioreactor highly depends on the cell characteristics as well as on the composition of the cell culture medium and the process conditions. As the metabolic activity o...

Biological Sex Patterns and Modern Living.

As every human is the product of the society in which he is born, a change in the communal life will be reflected in altered relationships between man and woman. The problems arising out of a change from primitive to twentieth century existence are of fundamental importance in present day marriage. Survival of the race is always an essential problem and other needs have to be subordinated if li...

MAKING MODERN LIVING POSSIBLE Programming Guide

Bioprocess microfluidics: applying microfluidic devices for bioprocessing

Scale-down approaches have long been applied in bioprocessing to resolve scale-up problems. Miniaturized bioreactors have thrived as a tool to obtain process relevant data during early-stage process development. Microfluidic devices are an attractive alternative in bioprocessing development due to the high degree of control over process variables afforded by the laminar flow, and the possibilit...

Low-cost microbioreactor for high-throughput bioprocessing.

The design of a microbioreactor is described. An optical sensing system was used for continuous measurements of pH, dissolved oxygen, and optical density in a 2 mL working volume. The K(L)a of the microbioreactor was evaluated under different conditions. An Escherichia coli fermentation in both the microbioreactor and a standard 1 L bioreactor showed similar pH, dissolved oxygen, and optical de...